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Enantiopure isoindolinones through Viedma ripening,

Chem. Eur. J. 20 (2014) 13527-13530

R.R.E. Steendam, M.C.T. Brouwer, E.M.E. Huijs, M. Kulka, H. Meekes,

W.J.P. van Enckevort, J. Raap, F.P.J.T. Rutjes, E. Vlieg,

Abstract: Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.