15-09

L. Sögütoglu, R.R. E. Steendam, H. Meekes, E. Vlieg, F.P.J.T. Rutjes,

Viedma ripening: a reliable crystallisation method to reach single chirality,

Chem.Soc.Rev. 44 (2015) 6723-6732

Abstract:

Crystallisation processes have evolved to practical methods that allow isolation of an enantiopure product in high yield. Viedma ripening in particular enables access to enantiopure products in a reliable way, simply through grinding of crystals in a solution. This tutorial review covers the basic principles behind asymmetric crystallisation processes, with an emphasis on Viedma ripening, and shows that to date many novel organic molecules can be obtained in enantiopure solid form.