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L. Spix, A.H. J. Engwerda, H. Meekes, W.J. P. van Enckevort, E. Vlieg,

Persistent reverse enantiomeric excess in solution during Viedma Ripening

Cryst. Growth Des. 16 (2016) 4752-4758

Abstract:

During Viedma ripening experiments on alanine 4-chlorobenzenesulfonic acid, the solution shows a small enantiomeric excess eel with the reverse sign as compared to the solid state enantiomeric excess. This reverse solution eel is persistent, even after the deracemization is complete, as long as the grinding is maintained. A model that includes thermodynamic chiral clusters and their incorporation into larger crystals of the same chirality explains this behavior. The size of the reverse eel is in good agreement with the estimated subcritical cluster distribution calculated on the basis of a

Boltzmann distribution and classical nucleation theory.